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Cake day: June 25th, 2025

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  • “It’s interesting right? SpaceX stock will continue to make you money while you sleep, so I just ponied up about 100 shares, bullied and threatened some judges, openly paid off some people that if they agreed this should happen, I’d give them money, and here we are: Self insured with a house of debt cards built around 100 shares of SpaceX stock, that I didn’t even have to give, I took my Tesla funding, ran that through the SpaceX money maker, and out popped 100 clean, laundered stock units, ready to “lobby” anyone I needed. Amazingly… It really is amazing when you think about it.”


  • As a reaction to their clickbait headline not telling you what the drug is, here’s the entire article:

    A common medication taken by about two million Americans, often off-label as a sleep aid, has been shown to cause potentially dangerous side effects that drag into the next day.

    The antipsychotic drug quetiapine, sold as Seroquel, is approved to treat schizophrenia, but it is frequently prescribed off-label for insomnia. About 75 percent of patients who take quetiapine receive it for sleep-related issues, not for its approved uses.

    Now, a world-first clinical trial from Australia has found that in people who take quetiapine at bedtime, the drug’s effects linger into the next morning, significantly reducing alertness and driving performance.

    Researchers at Flinders University found that while a low, 50-milligram dose of quetiapine modestly improved sleep quality and slightly reduced the severity of obstructive sleep apnea (OSA), it also caused notable next-day drowsiness and impaired driving ability.

    In the US alone, low-dose quetiapine is prescribed more than ten million times each year.

    Previous research has shown that taking antipsychotic medications off-label for insomnia and milder sleep issues can lead to unpleasant morning-after effects, including reduced breathing and poor work performance.

    The findings add to growing concerns about the drug’s safety, particularly for people who drive or operate machinery the morning after taking it.

    'There’s a growing belief that low-dose quetiapine is a relatively harmless way to help people sleep,’ Dr Cricket Fauska, lead author of the study from Flinders University, said. ‘Our results show it’s not that simple.’ Quetiapine (sold as Seroquel) is approved for schizophrenia and bipolar disorder, but it’s prescribed off-label for insomnia in about 75 percent of patients (stock image) +5 View gallery Quetiapine (sold as Seroquel) is approved for schizophrenia and bipolar disorder, but it’s prescribed off-label for insomnia in about 75 percent of patients (stock image) TRENDING Half of people with deadly ‘silent’ disease don’t know they have it 586 viewing now The lifestyle choice that raises risk of breast cancer by 60 per cent 13.7k viewing now Routine surgeries had by millions each year may accelerate memory loss 327 viewing now

    He added that, even though participants experienced longer sleep duration and fewer nighttime awakenings, they showed slower reaction times and a clear decline in simulated driving performance the following morning.

    Quetiapine is an atypical antipsychotic, meaning it belongs to a newer class of antipsychotic drugs that differ from older ‘typical’ antipsychotics in their receptor-binding profile and generally cause fewer movement-related side effects, such as a disorder called tardive dyskinesia. Read More EXCLUSIVE I took ADHD pills and antidepressants. No one warned coming off this fast would leave me in hell article image

    At low doses, however, quetiapine is frequently prescribed off-label for insomnia due to its potent antihistamine effects.

    The drug works primarily by strongly blocking histamine H1 receptors in the brain, the same mechanism behind many first-generation antihistamines found in sleep aids.

    By binding to and blocking these receptors, quetiapine reduces wakefulness and promotes sedation, helping people fall and stay asleep.

    However, this histamine blockade also explains the significant next-day sedation and cognitive impairment observed in studies, including this latest one, as the drug’s effects can linger well beyond the sleep period.

    Unlike traditional sleep medications that target GABA receptors, quetiapine’s broader receptor profile can also lead to side effects such as weight gain or metabolic changes, even at low doses.

    In the study, published in the Annals of the American Thoracic Society, researchers at Flinders University in Australia conducted a small but rigorous trial involving 15 people with both obstructive sleep apnea (OSA) and difficulty staying asleep. Earlier studies have found that using antipsychotic drugs off-label for insomnia or minor sleep problems can cause unpleasant next-day effects, such as shallow breathing and impaired work performance +5 View gallery Earlier studies have found that using antipsychotic drugs off-label for insomnia or minor sleep problems can cause unpleasant next-day effects, such as shallow breathing and impaired work performance

    Each participant spent two separate nights in a sleep lab, about a week apart.

    Before bed on one night, they took a 50mg dose of quetiapine; on the other night, they took a placebo pill.

    Neither the participants nor the researchers knew which pill was given on which night.

    The next morning, about 8.5 to 9.5 hours after taking the medication, everyone completed a ten-minute reaction-time test and a 30-minute driving-simulator task designed to mimic a monotonous rural night drive.

    The drug showed mixed effects.

    On the positive side, compared to placebo, quetiapine reduced the frequency of breathing pauses, known as the apnea-hypopnea index, by about 24 percent and improved sleep efficiency, meaning people spent more time actually asleep and less time awake during the night.

    However, the downsides were significant. The next morning, participants had slower reaction times on the vigilance test.

    On the driving simulator, their ability to stay centered in their lane worsened substantially, and they crashed nearly twice as often, with 55 crashes after quetiapine compared to 27 after placebo, though the crash increase was not statistically conclusive. Each line represents one participant. The left end shows their steering deviation after a placebo; the right end after quetiapine. Lines angling upward mean driving got worse. The purple arrow marks the average for healthy drivers, about 30 to 40cm. Quetiapine worsened average steering by 24 cm (72 vs 96), but individual results varied widely +5 View gallery Each line represents one participant. The left end shows their steering deviation after a placebo; the right end after quetiapine. Lines angling upward mean driving got worse. The purple arrow marks the average for healthy drivers, about 30 to 40cm. Quetiapine worsened average steering by 24 cm (72 vs 96), but individual results varied widely Each line represents a person in the study. The left end of the line shows their reaction time after taking a placebo. The right end shows their reaction time after taking quetiapine. On a 10-minute reaction time test, participants who took quetiapine were significantly slower to respond than those who took a placebo - 382 milliseconds versus 336 milliseconds. The wide range of results also suggests that some people are far more impaired than others +5 View gallery Each line represents a person in the study. The left end of the line shows their reaction time after taking a placebo. The right end shows their reaction time after taking quetiapine. On a 10-minute reaction time test, participants who took quetiapine were significantly slower to respond than those who took a placebo - 382 milliseconds versus 336 milliseconds. The wide range of results also suggests that some people are far more impaired than others

    ‘What was particularly concerning is that some people didn’t feel especially sleepy the next day, despite performing worse on objective tests,’ Fauska said.

    ‘That mismatch between how people feel and how they actually function poses a serious safety risk, especially when it comes to driving.’

    The study’s authors concluded that while a low dose of quetiapine may offer modest overnight benefits for sleep and breathing, it clearly impairs next-day alertness and driving ability.

    They warned that people should avoid driving or performing other safety-sensitive tasks for at least 9.5 hours after taking the drug.

    ‘What we’re learning is that treatment needs to be tailored – using the right approach, or combination of approaches, for the individual rather than defaulting to sedating medications,’ said Flinders University sleep health professor and senior author Dr Danny Ecker.











  • Thats because we basically gave our rail system to corporations so they only maintain them enough to not have shipments derailed, and they get priority during interchanges when consumer trains are approaching the same intersection tracks. I’ve taken trains where we had to wait an hour for freight trains to roll through before we got our chance to go.

    Maybe there’s other points in the video, but I didn’t have time to watch it.


  • This is the allure for me as well. The trackpads make it so I can play any style game I want on the handheld, which is amazing. I’m playing emulated console games, modern steam games and games from the 90’s early 2000’s that were designed with mouse and keyboard in mind. I wouldn’t want a faster device without the trackpads, as it would cut down on a lot od games i’d like to play.

    There’s no way you’re gonna be able to play Age of Empires, or similar games with joysticks, thats for sure.




  • PSA for anyone using a laptop during flights, the tray tables do not change angle or height when the person in front of you puts their seat all the way back. I almost had someone break my laptop screen a few years ago because the top of my screen got caught under the exposed edges where my tray table would fold up into, as the seat back came angling down towards my tray table. I was quick enough to be able to pull my laptop towards me and remove the screen before the full force was applied to the screen housing.



  • As a steamdeck owner, the ability to use the trackpads to play old keyboard/mouse games without having to sit at a computer, is great. I’ve been playing a lot of Dungeon Siege and Baldur’s Gate 2, released in early 2000’s with mouse/keyboard in mind, and they both work flawlessly.

    The new Steam Controller is a welcome addition because the old Steam Controller doesn’t have the same button and joystick layout, plus its missing buttons, compared to the steamdeck. So when you want to dock the steamdeck and play your favorite first person shooter for example, and game on the TV in the livingroom, there’s no controller until now that matches what you’ve become accustomed to expecting with muscle memory, from playing on the steam deck.