You can sort GitHub issues by most “upvoted” using this syntax:
is:issue is:open sort:reactions-+1-desc
Thanks to gromenauer for making me aware of it in this GitHub comment.
Full documentation for sorting GitHub issues and pull requests can be found here.
EDIT (2024-08-27T05:20Z): There are also UI options that enable sorting by most “upvoted”:
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On desktop (through a web browser):
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On mobile (through the app):
Yeah. I believe it should also work in the pull request search bar, but I haven’t checked.
EDIT (2024-08-27T05:21Z): I just checked, and yeah the Pull requests viewer has the same search option.