The one sub I miss. Wish there was a hexbear comm for it, as the lemmy.ml one has like 3 active users before it died over a year ago

They make quality stuff for the prices, an old job got a bioreactor (basically a carboy for homebrewing wired with sensors & computer-controlled pumps) for $25k from a Chinese manufacturer. They later sold it to the Open Insulin project & used the money to buy a textured vegetable protein extruder from China to make vegan deli meats. Both had kinda wonky unintuitive user interfaces, but they were solid pieces of hardware

Reminds me of the funny pharmacology of Navalny’s poisoning, according to the chemist that got crank called by Navalny & Bellingcat in that CNN documentary. The chemist said he smeared 10x the lethal dose in his blue underwear’s waistband yet it took an hour to take effect & he survived throughout the entire duration of the emergency landing at Omsk plus ambulance ride.

Gotcha, I didn’t consider the video call aspect cause my grillings were in front of 10 of my peers where I had to draw out the electron pushing mechanism for how the molecule I was researching produces hydrogen peroxide.

I did get it right after like 20 excruciating minutes standing in front of the whiteboard reasoning out the mechanism, but it was never previously taught to me by my PI.

The livestreamed collapse name is based on some old meme about how the future sucks & the only cool technology we have is some pocket screen to doomscroll the collapse of society & climate with.

I don’t get it?

I’m glad to see more Colonial Outcasts getting posted here, I’ve been enjoying its loose feel a bit like old Eyes Left was. A bit 👁️ that oft-recurring guest Elina Xenophontos follows Jackson Hinkle, but that’s petty stuff.

I’d like to consider myself a freak with an amazing memory but, yeah, that on the spot pressure/call-outs were especially rough in graduate-level sciences. I get the whole in-situ “determine the limits of your knowledge on the subject” but damn if it didn’t feel like the primary investigator of the lab I was in just saw me as a lab rat to poke and prod for his curiosity when I was presenting research updates.

Also not fun to learn I probably had test anxiety for my entire scholastic career & never had accomodations suggested to me until I was nearly done with my coursework :/

Oh shit, and here I was thinking ‘fuck you rocks’ lying just below the surface were the worst thing a paddler could encounter, not an ambush hervabore’s tusks goring your thigh then pulling you under!

Gundam (but Roman)-ass character names. Seeing it where some audience member has some conversation with Driver during the movie which seems curiously weird

lysdexamphetamine (Vyvanse) is an interesting prodrug version of Adderall that often gets joked about by Felix & a low dosage might address both the short half life of Ritalin while not keeping you too wired to sleep.

The strategy for Adderall XR is having slow release encapsulation, plus different amphetamine salts which take varied amounts of time to become active.

Vyvanse instead attaches a lysine amino acid to the amphetamine molecule, rendering it inert until an enzyme in your bloodstream cleaves off the lysine, yielding the active form.

This prodrug strategy eliminates variables that might affect the release rate of the active drug from an XR capsule before it hits your bloodstream, meaning you get a “spikier” release profile instead of a low & slow consistent dose curve. Variables like a lower stomach pH, which promotes quicker degradation of encapsulation material or how fast the various salts dissociate from the active amphetamine molecule. With the lysine prodrug it doesn’t matter how much of the prodrug enters your bloodstream, it’s release rate is tied to how quickly that enzyme can cleave the lysine off the amphetamine.

They’re a feddie plot to divide us spacenoids & steal money for dues that we could otherwise have spent on a PlayStation 17! I read it in the latest Q drop posted by those cyber newtypes at the 4Chanagan Institute

Inspiring words, oh great Degwin! With undying revolutionary zeal for the spacenoid cause, I shall triple my efforts as an optics tech at the colony laser!

Idk if you’re taking requests but if so can you have Degwin speak about his beautiful daughter, Kycillia, & future son in law Jared M’quve?

With the inherent biases present in any LLM training model, the issue of hallucinations that you’ve brought up, alongside the cost of running an LLM at scale being prohibitive to anyone besides private-state partnerships, do you think that will allay conspiracists’ valid concerns about the centralization of information access, a la the reduction in quality google search results over the past decade and a half?

GOOD advice. I called a uh, “pharmacological audible” switching from Sertraline (Zoloft) to Bupropion XR by asking an RN to prescribe the latter during my 1st quarter of pharm sci/med chem PhD after the Sertraline showed signs it definitely wasn’t working. Felt much better but they still mastered me out a couple years later. I went off it during COVID just to see how I’d fare without & was mostly fine at my 1st job out of school working at a drug delivery startup, but have been considering going back on it; like MeowZedong said, this is a small field & I feel like I’m having a hard time staying motivated to apply for job listings that may get as many as ~500 applicants—all more credentialed than I—ever since that 4 person startup I was working for went under last year.

One thing to note with Bupropion is skipping 4 days can cause mild amphetamine psychosis, so don’t learn that the hard way when transferring the prescription to a pharmacy that’s closed on weekends. 3-chloro- N-tert butylcathinone, where cathinone is the active ingredient of khat, might’ve been a giveaway with a pharmacophore like that!

Painful to read. You missed your chance to make a hot tub with your beam saber & invite them to skinny dip right then and there

Dr. Spoon’s more credentialed than my washed out academic career; my hating has been defeated by meritocracy!

The ghosties scared me as an 9 year old.

Not to mention meeting standards of purity and formulating your medication so it’s shelf stable and the active pharm ingredient can be distributed within the body effectively once the medicine is administered.

I’ve had similar thoughts as these jokers but with using bioreactors. Each time I conclude that the solution is a centralized manufacturing facility owned by workers to effectively produce at scale (and ensure you don’t poison people).

Sure, you’re not gonna build that misoprostol plant in Texas, but there’s other options to obtain properly-manufactured medication before you drink a mystery brew cooked up by an anarchist squatter named Spoon.

Absolutely, and I don’t see biohackers offering up cheap NMR or MS/MS detectors to solve the common issue of inadvertently making side products like MPTP when attempting to cook up MPPP or whatever, consequently injecting Parkinson’s into yourself. So you’re still bound by the enormous costs of getting an analytical lab stood up, despite using “AI” assisted synthetic software to substitute for real verification of each purified intermediate product. Also my other chem friend & I think that Vinni guy is an annoying ted-talk dude fwiw.