As the largest organ in the body, the skin can have a profound impact. The chemicals released by diseased and dysfunctional skin soon enter the bloodstream, where they wash around, damaging other tissues. Amid the ensuing systemic inflammation, chemicals from the skin can reach and harm organs that seem entirely unrelated, including your heart and brain.
Well thats it, I’m definitely staying out of the sun now!
Maybe I’m being too obtuse. Think about how prostheses might affect the sites they attach to the skin.