I would recommend posting this to the lemmy linux community @Linux

Lutris probably doesn’t have much to do in this case. It’s WINE that’s the important part.
Have not tried running autocad, so I can’t be of much of a help here.

I haven’t tried Autocad specifically, but complex non-game software tends to be a struggle. MS Office doesn’t even run. Autodesk software wouldn’t be the easiest to get running, and probably still have bugs if it does.

For Lutris, I would start by checking if theres even a script for it on there. Lutris basically just has a bunch of scripts to set a Wine prefix up with ideal settings for that software (and generally, just games). For compatibility, best check the databases like WineHQ and ProtonDB.

Couldn’t find much on ProtonDB about it. Accourding to WineHQ it varies a lot between versions: https://appdb.winehq.org/objectManager.php?sClass=application&iId=86

Based on that you could try, but I wouldn’t rely production on it. Even if it works well, it would easily break too. These kinda software is finicky and without stable positive results I would be careful.

If you need stability and not a hobby project, you could try FreeCAD if you want native Linux support, or run AutoCAD in a VM. VMware has functionality to make it look near-native while running on a Windows VM in the background. On the otherside, VirtualBox is free but can’t do that as smooth.